Pharmatalkradio

First recorded at the 4th annual IO Combinations 360° conference, this talk provided by Dr Kenneth Hance, GSK addresses agonistic strategies, T and NK cell redirection and the use of genetic/phenotypic assocations to identify novel target space in IO. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Laureen Ojalvo, EMD Serono provides an overview of the moleculte Bintrafusp alfa/M7824. This molecule is an innovative, first-in-class bifunctional fusion protein composed of an anti-PD-L1 mAb fused with 2 extracellular domains of TGF-βRII (a TGF-β “trap”). The mechanism of action, pre-clinical and phase 1 studies of this molecule is discussed as well as an overview of the next wave of clinical development. To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

In this podcast, first recorded at the 4th annual IO Combinations 360° conference, Dr Willem Overwijk, Nektar Therapeutics discusses Bempegaldesleukin (NKTR-214): harnessing the IL-2 pathway in combination immunotherapies. Topics include: Bempegaldesleukin: Structure and function of an engineered IL-2 cytokine prodrug providing sustained IL-2Rβγ-biased signalingPreclinical PK, PD, MOA and combination with PD-1 checkpoint inhibitionClinical PK, PD, clinical response data and biomarkers in patients with melanoma and bladder cancerCombinations under investigation To learn more about the upcoming IO Combinations 360° conference please visit, www.iocombinations360.com

First recorded at the fourth annual IO Combinations 360° conference, this panel moderated by Dr Daniel Chen, IGM Biosciences discusses advancing bispecifics for combination immunotherapy. This discussion covers the following topics: What are the types of bispecifics and what are the limitations?What are the toxicity related side effects?What are teh next steps/levels for bispecifics?What does the future hold for bispecifics? Panelists include: Julie Bailis, PhD, AmgenRajkumar Ganesan, PhD, Janssen Research & DevelopmentDavid Schaer, PhD, Pfizer To learn more about the 5th annual IO Combinations 360° conference please visit www.iocombinations360.com

In this podcast, you will hear a panel discussion from the 2019 IO Combinations 360° conference regarding how AI, machine learning and big data are used to inform combinations. Moderated by Matthew Albert, MD, PhD, Insitro Panelists: Edward Bowen, GSK Ryan Fukushima, Tempus Renée Deehan-Kenney, PhD, QuartzBio, part of Precision for Medicine To learn more about the 2020 IO Combinations 360° conference please visit www.iocombinations360.com

In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference with patients and advocates on weighing your care options and considering participation in a clinical trial. Some points include, Strategies and ideas to reduce the burden to patientsUnderstanding of clinical care with their physician?Communication, consent and data sharing Moderated by Cindy Geoghegan, Cancer Veteran, Patient Advocate Panelists: Allison Greiner Patient Advocate Sarah Larson, Director of Global Clinical Operations, Biogen and Cancer Veteran Kelly Piacsek, PhD, VP, Patient-Centered Research, Aurora Research Institute The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

In this podcast, you will hear a panel discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference on Understanding the Goals of Care Vs Research. The panelists explore points including, Goals for care vs goals for researchOversight and governanceIs there an ethical burden of breaking down the line between research and care?What is the hesitation behind embracing the blurring of this boundary?In areas like precision medicine, this is already blurring, how to manage?Hurdles stopping large companies from thinking about this– Is it practical? Ethical? Moderated by Jennifer Byrne, CEO and Founder, Javara Panelists: Greg Burke, MD, MSc, Chief Science Officer, Senior Associate Dean for Research, Wake Forest School of Medicine Amy Nordo, Director eSource Implementation, Pfizer The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

This 6 minute podcast summarizes what you can expect during the virtual Patients as Partners conference. Key topic areas include: BioPharma Strategies on Applying Patient Engagement Initiatives and Demonstrating ImpactDirect-to-Patient Clinical Trials Next Milestones and Actions to Get ThereMeasuring the Impact of Patient Engagement and Patient Centricity in Clinical Research and DevelopmentCurrent Efforts for Educating and Enrolling Diverse Populations in Clinical TrialsProgress on Patient Data OwnershipCollaborating with Site Partners & CROs to Increase Efficiencies, Provide Greater Value to Patients and Clinical TrialsProgress on the National Health Council’s Patient Engagement Fair Market Value InitiativeFDA Reports on the Latest Guidance Updates and New Agency Efforts on Patient Engagement Keynotes include: Dr Dara Richardson-Heron, PfizerDr Joanne Waldstreicher, Johnson & JohnsonDr Darryl Sleep, AmgenBarry Greene, Alnylam PharmaceuticalsRonnie Sharpe, Cystic Fibrosis AdvocateKen Getz, Tufts CSD

In this podcast, you will hear a session from the 2019 Clinical Research as a Care Option (CRAACO) conference on How to Integrate Industry-Sponsored Clinical Trials Into Your Health System to Give Patients the Best Options. Points include, How to build your programsHow to become an integrated care & research organizationHow to integrate clinical research into your care systemRoswell Park and TrialScout’s strategic partnership Speakers: Irfan Khan, MD, CEO and Founder, Circuit Clinical Doug Plessinger, Chief Clinical & Scientific Development Officer, Roswell Park/GBCT The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

In this podcast, you will hear a case study presentation from the 2019 Clinical Research as a Care Option (CRAACO) conference on how Sanford Health Systems has increased their clinical trial participation from 3% to 10% over the last 8 years by integrating clinical care and clinical research. Points include, Creating a system for all providers to work seamlesslyEducational programs and continual training across all areas of care and specialties for trial offeringsIdentifying gaps in trial availabilityAttracting providers who are interested in clinical research for their patientsNCORP site The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

In this podcast, you will hear a keynote presentation from the 2019 Clinical Research as a Care Option (CRAACO) conference. Dr Laura Esserman, the architect behind the I-SPY 2 TRIALTM has achieved remarkable progress with this clinical trial in improving the outcomes of early stage, breast cancer for patients who are at high risk for early recurrence. I-SPY 2 is also impacting far beyond breast cancer by increasing efficiencies that promise to accelerate the development and delivery of more effective therapies for other cancer types and a range of other diseases. This would not be possible without the integration of care and research. In this keynote session, hear this surgeon’s view on the future of integrating care and research. Speaker: Laura Esserman, MD, MBA, Director, UCSF Carol Franc Buck Breast Cancer Center; Alfred A. de Lorimier Endowed Chair in General Surgery; Professor of Surgery and Radiology, UCSF The 2020 CRAACO conference will be taking place April 27-28 in Raleigh, NC. Learn more about it

In this podcast, you will hear a session from the 2019 Clinical Research as a Care Option (CRAACO) conference. Jeff James, CEO of Wilmington Health, presented a case study on how they are streamlining the processes behind integrating clinical care and clinical research, including: Going from a fragmented patient journey to a streamlined oneHow to take the patient experience to “just making it another visit type”How to take study protocols and make them more native to EMRGeneral best practices for streamlining the process for patients and investigatorsWhat it took to actively normalize the flows and processes of clinical research The 2020 CRAACO conference will take place on April 27-28 in Raleigh, NC. Learn more here.

At the 2019 Clinical Research as a Care Option (CRAACO) conference, a panel discussed Barriers Health Systems Face in Integrating Clinical Care & Research, including: Financial barriers – Speaking to administration’s bottom lineHistorical barriers – Who are the key stakeholders that need to be converted into believers of the CRAACO movement?Logistical issues – How can we make study startup a more streamlined process?Culture change – Onboarding an outside group nested into an existing infrastructureDoes adding the offering of clinical trials disrupt the ability of the physicians in the clinics to have appropriate patient flow?How do you offer patients the options of clinical research?Insight from the front line of physicians seeing patients Moderated by: Lora Black, Senior Director of Clinical Research, Sanford Health Systems Panelists:  Greg Burke, MD, MSc, Chief Science Officer, Senior Associate Dean for Research, Wake Forest School of Medicine Adrian Hernandez, MD, MHS, Vice Dean for Clinical Researc

In this podcast, you will hear a discussion from the 2019 Clinical Research as a Care Option (CRAACO) conference on Effectively Democratizing Access to Clinical Trials. This panel covers how making clinical research a care option is the ultimate opening of access to clinical trials. Including points on: Current state of affairs: Gross underrepresentation of minorities 5-6% are represented in trials, but it should be closer to 40%What are the barriers to opening access?How can we educate underserved communities about clinical research?What are we doing to overcome this?Does offering these care options enhance access in a broad sense? Moderated by: Jennifer Sheller, MPH, Regional Head, North America, Merck Panelists: Jonathan Jackson, PhD, Director, CARE Research Center, Massachusetts General Hospital Cynthia Verst, PharmD, President, Design and Delivery Innovation, IQVIA The 2020 CRAACO conference will take place on July 13-14, 2020 in Raleigh, NC. Learn more here.

A new way of doing business was required to achieve the mission of serving patients suffering from rheumatoid arthritis. In this podcast, first recorded at the 2nd annual Drug Delivery West conference, William (Bill) Rich, Amgen and Daniele Fazio, Flex discuss how Amgen and Flex created an integrated, single team with co-executive sponsorship and overarching program management that enabled the successful development and launch of a novel combination product. To learn more about the 3rd annual Drug Delivery West conference happening May 17-18, 2021 in San Francisco, CA please visit www.drugdeliverywest.org

In this podcast, first recorded at the 2nd annual Drug Delivery West conference, Dr James Cunningham, Allergan leads a panel on exploring other routes of administration for ophthalmology. Discussion points include: Barries/challenges associated with drug delivery to the back of the eyeProlonging delivery & reducing frequency of administrationAlternative/less invasive routes of administration for delivery to the back of the eyeDelivery for emerging modalitiesImpact of delivery system design choices on development/scalabilityHow to effectively assess novel delivery approaches Panelists include: Dr James E Chastain, Novartis Institutes for BioMedical Research, IncDr Susan Crowell, GenentechDr Viral Kansara, Clearside Bio To learn more about the 3rd annual Drug Delivery West conference happening May 17-18, 2021 in San Francisco, CA please visit www.drugdeliverywest.org

First recorded at the 2nd annual Drug Delivery West conference, Dr Carlos Schuler, InCarda Therapeutics discusses transforming cardiovascular treatment with pulmonary delivery. This podcast discusses: Pioneering a novel approach for treating cardiovascular conditions by the oral inhalation routeWill be the ONLY non-invasive, self administered product for acute management of Paroxysmal Atrial Fibrilation, providing rapid cardioversionIn Phase 2: Dose dependent conversion observedWorking on enhancements to greatly improve speed of delivery To learn more about the 3rd annual Drug Delivery West conference happening May 17-18, 2021 in San Francisco, CA please visit www.drugdeliverywest.org

In this podcast, first recorded at the 2nd annual Drug Delivery West conference, Dr Isabelle Aubert, University of Toronto, provides an introduction to MRI-guided focused ultrasound (MRIgFUS) and reviews applications in preclinical models of neurodegenerative disorders where therapeutic molecules, gene therapy vectors, and progenitor cells are injected intravenously and delivered from the blood to targeted areas of the brain with MRIgFUS. Dr Aubert will describe the seminal work of the Sunnybrook team on MRIgFUS-BBB modulation, without exogenous therapeutic, leading to glial plasticity, amyloid pathology reduction, hippocampal neurogenesis and improved cognitive functions in a preclinical model of Alzheimer's disease.  To learn more about the 3rd annual Drug Delivery West conference happening May 17-18, 2021 in San Francisco, CA please visit www.drugdeliverywest.org

Bringing clinical research as a care option to patients is arguably the greatest change we can collaborate on to give patients the best choices of care and to help make clinical trial options easier for providers to access. This panel, moderated by Dr Irfan Khan, TrialScout and recorded at the 6th annual Patients as Partners US conference, will explore how to collaborate to create better strategies to inform patients on clinical research and trial participation.  Key talking points include: Demystifying physician/research burdens. What are physicians really up against?How to better inform physicians of clinical research and trialsHow can more physicians get involved in research and communicate the offering of clinical trials?Patient perspectives on clinical research as a care option Panelists include: Dr Alistair Lindsay, GSKLinnea Olson, Patient AdvocateDr Sanjay Sethi, University of BuffaloDr Kelly Wade, Children's Hospital of Philadelphia & CHOP Newborn Care at Pennsylvania Hospital/ University of Pen

In this fireside chat, moderated by Ken Getz, Tufts CSDD/CISCRP and recorded at the 6th annual Patients as Partners US conference discusses the following: How do you create a culture that enables new strategic, operating and organizational models to flourish?How do you drive a patient-centric organization while continuing to execute on business imperatives? How do you balance that?How do you drive a patient-centric agenda through the value chain?How do you engage your employees and empower them to implement patient involvement strategies? And, how do you enlarge the outlook of employees who are stuck in status quo? Guests include: Julie Gerberding, MD, MPH, MerckJayne Gershkowitz, Amicus Therapeutics To learn more about the 7th annual Patients as Partners US conference happening June 29-30, 2020 in Philadelphia, PA please visit www.patientsaspartners.org