Empowered Patient Podcast

Developing Combination Therapies Targeting Hallmarks of Aging to Address Multiple Age-Related Diseases with Dr. Ann Beliën Rejuvenate

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Synopsis

Dr. Ann Beliën, Chief Executive Officer and Founder at Rejuvenate Biomed, is addressing the underlying biology of aging including mechanisms like mitochondrial health, cell-cell communication and inflammation in order to promote healthy aging. Taking a combination therapy approach, Rejuvenate is using AI-enable drug discovery to address multiple pathways that are involved in aging. Their lead drug candidate is a treatment for sarcopenia with plans to assess impact on other age-related biomarkers. Ann explains, "The biology of aging indeed is being defined by 12 hallmarks. These 12 hallmarks are pathways where you see that the functioning is deteriorating. One of them is mitochondrial health. So, the mitochondria are there to create energy in your cells to make sure that they work to an optimal base. That’s a very important element that we need to address." "Another very important one for us is cell-cell communication. So, for instance, in sarcopenia, one of the diseases we study, it’s very important that you