Tacc Podcasts

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. Jorge Salazar, a science writer at TACC, hosts the podcast. Much remains to be discovered on how the HIV-1 virus infects our cells. Scientists know that it slips past the defenses of our immune system, entering white blood cells to deliver its genetic payload and hijack the cell's transcription machinery that in turn cranks out copies of viral RNA and new HIV-1 viruses. But many of the details remain hazy. A major experimental made in 2021 shed some light on the mystery and found that the viral capsid, a protein envelope protecting its RNA genome, remains intact all the way into the nucleus of the target cell. Ultimately, the capsid has to stay stable long enough to take its deadly genetic cargo into the nucleus of the cell. But in the end, it has to break apart to release its genetic material. What sci