The Psych Central Show: Candid Chat On Mental Health & Psychology

What happens when therapy and medication don’t work? Treatment-resistant depression can feel like a dead end — but it’s not. In this episode, clinical psychologist and ADAA member expert Dr. Jill Emanuele unpacks the nuanced differences between sadness, grief, and major depressive disorder — and why misusing these terms can delay real help.But the conversation doesn’t stop there. What happens when traditional treatments for depression don’t work? You’ve probably heard the term treatment-resistant depression, and it may sound terrifying. Dr. Emanuele and host Gabe Howard dig deep into what this label actually means — and spoiler alert: It’s more about strategy than severity. You’ll also discover lesser known but evidence-backed options that go beyond talk therapy and antidepressants, including: transcranial magnetic stimulation (TMS) ketamine and esketamine treatments radically open dialectical behavior therapy (RO-DBT) electroconvulsive therapy (ECT) without the Hollywood horror spin psychede